Shortlist by what you need
Start here if you know why you are leaving Tempus AI.
Want the closest match?
TriomicsMost similar to Tempus AI in what it does, its category and its price.
Visit (opens Triomics in a new tab)Need a free plan?
OpenEvidenceHas a free plan, rated 4.4 out of 5. Tempus AI has none.
Visit (opens OpenEvidence in a new tab)Want the best rated?
Hippocratic AIRated 4.3 out of 5 in our review, against 4.3 for Tempus AI.
Visit (opens Hippocratic AI in a new tab)
At a glance
Green means better than Tempus AI, red means worse. Prices are starting prices per month.
| Tool | Our rating | Starts at | Free plan | Best for | Compare |
|---|---|---|---|---|---|
 Tempus AIBaseline | 4.3 | Not listed | No | Publicly traded on Nasdaq, guiding to $1.6 billion in 2026 revenue | |
| Triomics | 4.0−0.3 | Not listed | No | AI for oncology workflows, supporting clinical trial matching and cancer care decisions. | vs Tempus AI |
 SOPHiA GENETICS | 3.9−0.4 | Not listed | No | AI genomic analytics at 98-99% accuracy, deployed across 1,000+ healthcare institutions in 75+ countries - 2.6 million-plus genomic profiles analyzed to date. | vs Tempus AI |
 Paige | 4.1−0.2 | Not listed | No | Digital pathology AI co-pilot from Memorial Sloan Kettering researchers, acquired by Tempus in 2025 | vs Tempus AI |
| Hippocratic AI | 4.3Same | Not listed | No | 115 million patient interactions with zero safety incidents, and it still won't diagnose | vs Tempus AI |
| OpenEvidence | 4.4+0.1 | Free | YesTempus AI has none | Used by 40% of US physicians, doubling its valuation to $12B in under a year | vs Tempus AI |
 Zephyr AI | 4.0−0.3 | Not listed | No | Precision medicine from real-world data, with interpretable models and no new assays. | vs Tempus AI |
 Bioptimus | 4.2−0.1 | Not listed | No | Foundation models for biology spanning molecular, cellular and tissue scales | vs Tempus AI |
 Cofactor AI | 4.0−0.3 | Not listed | No | Cofactor AI reads clinical documentation and payer policies to draft evidence-backed appeals for denied hospital insurance claims. | vs Tempus AI |
The alternatives in detail
In order of how closely each one matches Tempus AI.
Triomics
4.0Not listed
vs Tempus AI−0.3
AI for oncology workflows, supporting clinical trial matching and cancer care decisions.
- AI built specifically for oncology rather than general medicine
- Clinical trial matching against unstructured patient records
- Structuring of oncology data for downstream decision support
Trial matching addresses a real and higher-priced manual bottleneck
Clinical deployment requires validation and governance review
SOPHiA GENETICS
3.9Not listed
vs Tempus AI−0.4
AI genomic analytics at 98-99% accuracy, deployed across 1,000+ healthcare institutions in 75+ countries - 2.6 million-plus genomic profiles analyzed to date.
- SOPHiA DDM - AI genomic and radiomic analysis platform
- 98-99% accuracy across 2.6M+ analyzed genomic profiles
- Oncology coverage - solid tumors, blood cancers, hereditary cancers, liquid biopsy
Accuracy claims are backed by scale (2.6M+ profiles), not a small validation sample
No published pricing - an institutional sales process
Paige
4.1Not listed
vs Tempus AI−0.2
Digital pathology AI co-pilot from Memorial Sloan Kettering researchers, acquired by Tempus in 2025.
- Paige Alba AI co-pilot for digital pathology tissue-slide analysis
- Cancer diagnosis, tissue subtyping, and molecular biomarker discovery support
- Founded in 2017 by researchers from Memorial Sloan Kettering Cancer Center
Research pedigree from Memorial Sloan Kettering lends real clinical credibility
Enterprise-only pricing requires a sales conversation before evaluation
Hippocratic AI
4.3Not listed
vs Tempus AISame
115 million patient interactions with zero safety incidents, and it still won't diagnose.
- Patient-facing AI agents for pre-visit intake, follow-up, and check-ins
- Deliberately restricted from prescribing or diagnosing by design
- 115 million-plus clinical patient interactions with no reported safety issues
Non-diagnostic scope reduces liability risk compared to diagnostic AI agents
Enterprise pricing requires a sales conversation, no published self-serve rate
OpenEvidence
4.4Free
vs Tempus AI+0.1Free plan
Used by 40% of US physicians, doubling its valuation to $12B in under a year.
- Point-of-care clinical answers grounded in peer-reviewed literature with citations
- 760,000 registered US physicians, roughly 40% of all US doctors
- Approximately 18 million clinical consultations handled monthly
Free access for physicians removes cost as a barrier to point-of-care use
Monetized through pharmaceutical advertising, which some clinicians may view with caution
Zephyr AI
4.0Not listed
vs Tempus AI−0.3
Precision medicine from real-world data, with interpretable models and no new assays.
- Multi-modal real-world data integration
- Interpretable machine learning models
- Discovery, validation and deployment coverage
Interpretable models, which is what makes a target hypothesis actionable
No published pricing, contact only
Bioptimus
4.2Not listed
vs Tempus AI−0.1
Foundation models for biology spanning molecular, cellular and tissue scales.
- Foundation models trained across molecular, cellular and tissue scales
- Digital pathology models for research and trial workflows
- Transfer learning that reuses existing imaging and omics archives
Cross-scale model design rather than one narrow task classifier
Requires in-house validation on local cohorts before clinical reliance
Cofactor AI
4.0Not listed
vs Tempus AI−0.3
Cofactor AI reads clinical documentation and payer policies to draft evidence-backed appeals for denied hospital insurance claims.
- AI review of clinical documentation against payer policy
- Automated appeal letter drafting
- Denial pattern tracking across payers
Targets a documented, higher-priced pain point in hospital billing
Pricing is undisclosed and requires a sales conversation
FAQ
Questions people ask
Is Tempus AI free?
Tempus AI does not list a free plan. Check its pricing page for current plans.
What is the best free alternative to Tempus AI?
OpenEvidence is the highest-rated alternative here with a free plan (4.4 out of 5).
How did you pick these alternatives?
We match tools on what they do, their category and their price, using the details in our directory. Ratings come from our reviews and reader reviews.